Reprogenetics

Experts in Preimplantation Genetic Diagnosis

This section is for current and potential patients of Reprogenetics. Here you will find information that will answer questions you may have about our services.

At Reprogenetics, our personnel have been performing PGD since 1991 and were the first to develop PGD tests for aneuploidy and translocations. To date Reprogenetics has performed diagnosis of over 20,000 PGD cycles, more than any other PGD laboratory in the world. When performed by Reprogenetics, PGD significantly increases implantation rates and decreases spontaneous abortions. We have a record unmatched by any other Preimplantation Genetics Diagnosis reference center.

Reprogenetics was the first Laboratory, and still one of the few, to be licensed by the State of New York Department of Health to perform Preimplantation Genetic Diagnosis for any indication (aneuploidy, translocations, or gene defects), which at present is the only agency in the US regulating PGD. Reprogenetics provides PGD services to more than 150 IVF centers in the US, including most of those with the best pregnancy outcomes. We are recognized as leaders in our industry, and we continue to innovate to help achieve the best outcomes for our patients.

For patients undergoing IVF, Reprogenetics’ services may be able to help improve your chances of achieving pregnancy and giving birth to a happy, healthy child. Our team is the worldwide leader in PGD, and we work hard to help ensure the health of your child. Find out more about Reprogenetics today.

To help determine which test might be right for you, let us know if you and your partner are trying to:

Reduce the chance of miscarriage or recurrent pregnancy loss.

Reduce the chance of down syndrome or chromosomally abnormal conception.

Improve my chances of conceiving a chromosomally normal fetus.

Replace fewer embryos.

Screen for a known chromosome translocation.

Avoid passing on a single gene disorder.

Utilize HLA typing for savior sibling embryos.

Screen sperm for aneuploidy ratios.

Obtain testing on the products of conception.

Chromosomal Rearrangements

PGD for Chromosomal Rearrangements

Chromosomal rearrangements such as reciprocal/Robertsonian translocations and pericentric and paracentric inversions are well-recognized forms of genetic abnormality. Preimplantation genetic diagnosis can be used to detect chromosomal rearrangements in embryos with the aim of transferring only normal/balanced ones for the establishment of a healthy pregnancy. A large number of cases has been carried out since the first clinical application of PGD for chromosomal rearrangements. Different studies reporting on the outcome of PGD cases for translocation carriers have demonstrated an increase in the chances of sustaining a pregnancy to full term: 85% of pregnancies on average were lost before PGD, while only 0-25% miscarried after PGD. Furthermore, PGD reduces the time needed for carriers of structural chromosome abnormalities to achieve a sustained pregnancy. Studies have shown that patients undergoing PGD achieve pregnancy in an average of 1.2-1.4 IVF cycles (<4 months) while patients without PGD require a much longer interval (mean 4-6 years). Reprogenetics offers PGD for a wide range of chromosomal rearrangements (including Robertsonian and reciprocal translocations and inversions) through utilization of array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH) technologies.

Reprogenetics has a staff of genetic counselors with specific expertise in PGD to serve the needs of its clients. Although Reprogenetics assumes no obligation to advise you as to your legal requirements as to the provision of PGD test, PGD counseling is recommended for every patient undergoing PGD. For patient convenience, the consultations are conducted by telephone and include a discussion about how the test will be performed, what it will indicate and a review of the applicable Reprogenetics data. A letter will be sent to document such consultations. This service can be customized when necessary.

At Reprogenetics, we believe in complete transparency concerning the efficacy of our tests and results. To that end, we make a point of publishing all clinical results, error rates, and technical advances. Our commitment to visibility and academic excellence contributes to our reputation as the leader in PGD.

Recent Publications

  • Colls P, Goodall N, Zheng X, Munné S (2009) Increased efficiency of preimplantation genetic diagnosis for aneuploidy by testing 12 chromosomes. Reprod Biomed Online 19:532-538
  • Colls P, Silver L, Olivera G, Weier J, Escudero T, Goodall N, Tomkin G, Munné S (2009)Preimplantation genetic diagnosis of gender selection in the united states. Reprod Biomed Online 19:16-22
  • Colls P, Silver L, Olivera G, Weier J, Escudero T, Goodall N, Tomkin G, Munné S (2010)Preimplantation genetic diagnosis of gender selection in the united states. Reprod Biomed Online In press
  • Ferraretti AP, Gianaroli L, Magli C, Farfalli V, Lappi M, Munné S (2008) PGD for chromosome anomalies. In: Infertility and Assisted Reproduction. Edited by: Rizk B, Garcia-Velasco J, Sallam H, Makrigiannakis A. chapter 65, pp. 643-656
  • Fischer J, Colls P, Escudero T, Munné S (2010) Preimplantation Genetic Diagnosis (PGD) improves pregnancy outcome for translocation carriers with a history of recurrent losses. Fertil Steril, 94:283–9
  • Fragouli E, Alfarawati S, Katz-Jaffe M, Stevens J, Colls P, Goodall N, Tormasi S, Gutierrez-Mateo C, Prates R, Schoolcraft WB, Munné M, Wells D (2010) Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure. Fertil Steril 94:875–87
  • Fragouli E, Escalona A, Gutierrez-Mateo C, Tormasi S, Alfarawati S, Sepulveda S, Noriega L4, Garcia J, Wells D, Munné S (2009) Comparative genomic hybridization of oocytes and first polar bodies from young donors. Reprod Biomed Online, 18: 228-237
  • Garrisi GJ, Colls P, Ferry KM, Zheng X, Garrisi MG, Munné S (2009) Effect of infertility, maternal age and number of previous miscarriages on the outcome of preimplantation genetic diagnosis for idiopathic recurrent pregnancy loss. Fertil Steril 92:288-295
  • Gutierrez C; Sánchez-García J; Fischer J; Tormasi S; Cohen J, Ph.D.; Munné S; Wells D (2009) Preimplantation genetic diagnosis (PGD) of single gene disorders: experience with over 200 cycles conducted by a reference laboratory in the United States. Fertil Steril 92:1544–56
  • Gutiérrez-Mateo C, Colls P, Sánchez-García J, Escudero T, Prates R, Wells D, Munné S (in press) Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos. Fertil Steril in press
  • Lopez P, Munné S (2008) Eficiencia del diagnostico preimplantacional (DGP) en infertilidad. In: Fertilidad y Reproducción asistida. Lerner J, Urbina MT Eds. Sociedad de Obstetricia Y Ginecologia de Venezuela. Editorial Medica Panamericana, Venezuela. Pp 573-575 (ADD SPANISH FLAG BESIDES IT)
  • Magli MC, Gianaroli L, Crippa A, Munne S, Robles F, Ferraretti AP (2010) Aneuploidies of chromosomes 1, 4 and 6 are not compatible with human embryos’ implantation. Fertil Steril In press
  • McWeeney DT, Munné S, Miller R, Cekleniak NA, Contag SA, Wax JR, Polzin WJ, Watson WJ (2009) Pregnancy Complicated by Triploidy: A Comparison of the Three Karyotypes. Am J Perinatology 9:641-645
  • Munné S (2008) Improving pregnancy outcome for IVF patients with Preimplantation genetic screening. Expert Rev. OB Gyn 3:635-646
  • Munné S (2009) Preimplantation genetic diagnosis for infertility (PGS). In: Current Status of Preimplantation Genetic Diagnosis (PGD) Harper J (Ed). Cambridge University Press. Chapter 13, pp: 203-229
  • Munné S (2010) Overview of preimplantation genetic diagnosis. Expert Rev. Obstet. Gynecol. 5:403–408
  • Munné S, Fragouli E, Colls P, Katz M, Schoocraft W, Wells D (2010) Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test. Reprod Biomed Online 20, 92– 97
  • Munné S, Fragouli E, Colls P, Katz M, Schoocraft W, Wells D (2010) An improved 12-chromosome FISH test could detect 91% of aneuploid blastocysts. Reprod Biomed Online 20, 92– 97
  • Munné S, Howles CM, Wells D (2009) The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy. Cur Op Ob Gyn 21:442-449
  • Munné S, Tomkin G, Cohen J (2009) Selection Of Embryos By Morphology Is Less Effective Compared To A Combination Of Aneuploidy Testing And Morphology Observations. Fertil Steril 91:943-945
  • Munné S, Wells D, Cohen J (2010) Technology requirements for preimplantation genetic diagnosis to improve art outcome. Fertil Steril 94:408–30
  • Schoolcraft WB, Fragouli E, Stevens J, Munné S, Katz-Jaffe MG, Wells D (2010) Clinical application of comprehensive chromosomal screening at the blastocyst stage. Fertil Steril, 94:1700–1706
  • Schoolcraft WB, Katz-Jaffe MG, Stevens J, Rawlins M, Munné S (2009) Preimplantation genetic diagnosis for aneuploidy screening: a randomized prospective trial. Fertil Steril 92:157-162
  • The Preimplantation Genetic Diagnosis International Society (PGDIS*) (2008)Guidelines for good practice in PGD: program requirements and laboratory quality assurance. Reproductive Biomed Online 16:134-147 (*Drs. Munné and Cohen are officers in that society and prepared this document)
  • Weghofer A, Munné S, Brannath W, Chen S, Barad D, Cohen J, Gleicher N (2009) The impact of LH-containing gonadotropin stimulation on
  • AbdelhadiI I, Colls P, Sandalinas M, Escudero T, Munné S. Preimplantation genetic diagnosis of numerical abnormalities for 13 chromosomes. Reprod Biomed online, 2003: 6:226-231
  • Bahçe M, Cohen J, Munné S (1999) PGD of aneuploidy: were we looking at the wrong chromosomes? J. Assisted Reprod Genet. 16: 176-181
  • Bahçe M, Escudero T, Sandalinas M, Morrison L, Legator M, Munné S (2000) Improvements of preimplantation diagnosis of aneuploidy by using microwave-hybridization, cell recycling and monocolor labeling of probes. Molec Human Reprod 9:849-854
  • Benadiva C, Kligman I, Grifo J, Munné S (1996) aneuploidy 16 in human embryos increases significantly with maternal age. Fertil. Steril. 66:248-255
  • Bermúdez MG, Wells D, Malter H, Munné S, Cohen J, Steuerwald NM (2004) Expression Profiles of Individual Human Oocytes using Microarray Technology. Reproductive Biomedicine Online 8:325-337
  • Cassel MJ, Munné S, Fung J, Weier HUG (1997) Carrier-specific breakpoint-spanning DNA probes: an approach to preimplantation genetic diagnosis in interphase cells. Human Reprod 2019-2027
  • Chen SH, Escudero T, Cekleniak NA, Sable DB, Garrisi MG, Cohen J, Munné S (2005) Maternal balanced translocation is a risk factor for poor response to ovarian stimulation. Fertil Steril 83:1504-1509
  • Cohen J, Grifo J (2007) Multicnetre trial of preimplantation genetic screening reported in the New England Journal of Medicine: an in depth look at the findings. Reproductive Biomed Online 15:365-366
  • Cohen J, Scott R, Alikani M. Schimmel T, Munné S, Levron J, Wu L, Brenner C, Warner C, Willadsen S (1998) Ooplasmic transfer in mature human oocytes. Molec Human Reprod 4: 269-280
  • Cohen J, Wells D, Munné S (2007) Removal of two cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests employed to enhance implantation rates. Fertil Steril, 87:496-503
  • Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munné S (2007) increased efficiency of preimplantation genetic diagnosis for infertility using “no result rescue”. Fertil Steril. 88:53-61
  • Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munné S (2007) increased efficiency of preimplantation genetic diagnosis for infertility using “no result rescue”. Fertil Steril. 88:53-61
  • Colls P, Sandalinas M, Pagidas K, Munné S (2004) PGD analysis for aneuploidy in a patient heterozygous for a polymorphism of chromosome 16 (16qh-). Prenat Diagn 24:741-744
  • Dailey T, Dale B, Cohen J and Munné S (1996) Association between non-disjunction and maternal age in meiosis-II human oocytes detected by FISH analysis. Am.J.Hum.Genet, 59:176-184
  • Escudero T, Abdelhadi I, Sandalinas M, Munné S (2003) Predictive value of sperm chromosome analysis on the outcome of PGD for translocations. Fertil Steril 79: supl 3:1528-1534
  • Escudero T, Estop A, Fischer J, Munné S (2008) Preimplantation Genetic Diagnosis for complex chromosome rearrangements. Am J Medical Genetics 146a:1662-1669
  • Escudero T, Lee L, Carrel D, Blanco J, Munné S (2000) Analysis Of Chromosome Abnormalities In Sperm And Embryos From Two 45,XY,t(13;14)(q10;q10) Carriers. Prenat Diagn 20:599-602
  • Escudero T, Lee M, Stevens J, Sandalinas M, Munné S (2001) Preimplantation Genetic diagnosis of pericentric inversions. Prenatal Diagnosis 21:760-766
  • Escudero T, Lee Michael L, Sandalinas S, Munné S (2000) Female gamete segregation in two carriers of translocations involving 2q and 14q. Prenat Diagn, 20:235-237
  • Estop AM, Munné S, Cieply KM, Vandermark KK, Lamb AN, Fisch H (1998) Meiotic products of Klinefelter 47,XXY male as determined by sperm fluorescence in-situ hybridization analysis. Human Reprod. 13: 124-127
  • Gianaroli L, Magli MC, Ferraretti AP, Fiorentino A, garrisi J, Munné S (1997)Preimplantation genetic diagnosis increases the implantation rate in human in vitro fertilization by avoiding the transfer of chromosomally abnormal embryos. Fertil.Steril. 68:1128-1131
  • Gianaroli L, Magli MC, Ferraretti AP, Munné S (1999) Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with poor prognosis: identification of the categories to which it should be proposed. Fertil. Steril. 72:837-844
  • Gianaroli L, Magli MC, Munné S, Fiorentino A, Montanaro N, Ferraretti AP (1997) Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy? Hum Reprod 12:1762-1767
  • Gianaroli L, Magli MC, Munné S, Fortini D, Ferraretti AP (1999) Advantages of day four embryo transfer in patients undergoing preimplantation genetic diagnosis of aneuploidy. J. Assisted Reprod Genet 16:170-175
  • Gianaroli L, Munné S, Magli MC, Ferraretti AP (1997) Preimplantation genetic diagnosis of aneuploidy and male infertility. Int.J.Androl. 20:Suppl.3:31-34
  • Grifo JA, Tang YX, Munné S, Alikani M, Cohen J , Rosenwaks Z (1994) Healthy deliveries from biopsied human embryos. Hum.Reprod. 9:912-916
  • Gutiérrez CM, Wells D, Benet J, Sánchez-García JF, Bermúdez MG, Belil I, Egozcue J, Munné S, Navarro J (2004) Reliability of Comparative Genomic Hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes. Human Reprod 19:2118-2125
  • Gutiérrez-Mateo C, Benet J, Wells D, Colls P, Bermúdez MG, Sánchez-García JF, Egozcue J, Navarro J, Munné S (2004) Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis. Human Reprod 19:2859-2868
  • Gutiérrez-Mateo C, Gadea L, Benet J, Wells D, Munné S, Navarro J (2005) Aneuploidy 12 in a Robertsonian (13;14) carrier: Case Report. Human Reprod 20:1256-1260
  • Kligman I, Benadiva C, Alikani M, Munné S (1996) The presence of multinucleated blastomeres in human embryos correlates with chromosomal abnormalities. Human Reprod, 11:1492-1498.
  • Lee M, Munné S (2000) Pregnancy after polar body biopsy and freezing and thawing of human embryos. Fertil Steril 73:645-647
  • Magli MC, Gianaroli L, Ferraretti AP, Fortini D, Munné S (1999) Impact of blastomere biopsy and cryopreservation techniques on human embryo viability. Human Reprod. 14:770-773
  • Magli MC, Gianaroli L, Munné S, Ferraretti AP (1998) Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients. J Assist Reprod Genet 15:297-301
  • Magli MC, Sandalinas M, Escudero T, Morrison L, Ferraretti AP, Gianaroli L, Munné S (2001) Double locus analysis of chromosome 21 for preimplantation genetic diagnosis of aneuploidy. Prenatal diagnosis 21:1080-1085
  • Márquez C, Cohen J, Munné S (1998) Chromosome identification on human oocytes and polar bodies by spectral karyotyping. Cytogenet Cell Genet 81:254-258
  • Márquez C, Sandalinas M, Bahçe M, Alikani M, Munné S (2000) Chromosome abnormalities in 1255 cleavage-stage human embryos. Reproductive Biomedicine Online 1:17-27
  • Munné S (2001) Preimplantation genetic diagnosis of Structural abnormalities. Molec Cell endocrinol 183: S55-S58
  • Munné S (2002) preimplantation genetic diagnosis of numerical and structural chromosome abnormalities. Reprod Biomed Online 4:183-196
  • Munné S (2003) Preimplantation Genetic Diagnosis and Human implantation – A review. Placenta 24: S70-76
  • Munné S (2005) Analysis of the segregation of chromosomes during preimplantation genetic diagnosis in both male and female translocation heterozygotes. Cytogenetics and Genomic Res 305-309
  • Munné S (2006) Chromosome abnormalities and their relationship to morphology and development of human embryos. Reproductive Biomedicine Online 12:234-253
  • Munné S and Cohen J (1998) Chromosome abnormalities in human embryos. Human Reprod Update. 4: 842-855
  • Munné S, Alikani M, Tomkin G, Grifo J, Cohen J (1995) Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil.Steril., 64:382-391
  • Munné S, Alonso ML, Grifo J (1996) case report: unusually high rates of aneuploid embryos in a 28-year old woman with incontinentia pigmenti. Cytogenet. Cell Genet., 72:43-45
  • Munné S, Ary J, Zouves C, Escudero T, Barnes F, Cinioglu C, Ary B, Cohen J (2006) Wide range of chromosome abnormalities in the embryos of young egg donors. Reproductive Biomed Online, 12:340-346
  • Munné S, Chen S, Fischer J, Colls P, Zheng X, Stevens J, Escudero T, Oter M, Schoolcraft W, Simpson JL, Cohen J (2005) Preimplantation genetic diagnosis reduces pregnancy loss in women 35 and older with a history of recurrent miscarriages. Fertil Steril 84:331-335
  • Munné S, Cohen J (2004) The status of Preimplantation Genetic Diagnosis in Japan: a criticism. Reprod Biomed Online 9:258-259
  • Munné S, Cohen J, Sable D (2002) Preimplantation Genetic Diagnosis for advanced maternal age and other indications. Fertil Steril 78:234-236
  • Munné S, Dailey T, Finkelstein M, Weier HUG (1996) Reduction in signal overlap results in increased FISH efficiency: implications for preimplantation genetic diagnosis. J. Assisted Reprod. Genet. 13:149-156.
  • Munné S, Dailey T, Sultan KM, Grifo J, Cohen J.(1995) The use of first polar bodies for preimplantation diagnosis of aneuploidy. Human Reprod. 10:1015-1021
  • Munné S, Escudero T, Fischer J, Chen S, Hill J, Stelling JR, Estop E (2005) Negligible interchromosomal effect in embryos of Robertsonian translocation carriers. Reprod Biomed Online 10:363-369
  • Munné S, Escudero T, Pere C, Xuezhong Z, Oter M, Garrisi M, Barnes F, Zouves C, Werlin L, Magli C, Cohen J (2004) Predictability of Preimplantation Genetic Diagnosis of Aneuploidy and Translocations on Prospective Attempts. Reprod Biomed Online 9:645-651
  • Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000) Gamete segregation in female carriers of Robertsonian translocations. Cytogenet Cell Genet 90:303-308
  • Munné S, Fischer J, Warner A, Chen S, Zouves C, Cohen J, And referring centers PGD group (2006) Preimplantation Genetic Diagnosis Significantly Reduces Pregnancy Loss in Infertile Couples: A Multi-Center Study. Fertil Steril 85:326-332
  • Munné S, Fung J, Cassel MJ, Márquez C, Weier HUG (1998) Preimplantation Genetic Analysis of Translocations: Case-Specific Probes for Interphase Cell Analysis. Human Genet, 102:663-674
  • Munné S, Gianaroli L, Tur-Kaspa I, Magli C, Sandalinas M, Grifo J, Cram D, Kahraman S, Verlinsky Y, Simpson JL (2007) Sub-standard application of PGS may interfere with its clinical success. Fertil Steril 88:781-784
  • Munné S, Grifo J, Cohen J, Weier HUG (1994) Chromosome abnormalities in Arrested Human Preimplantation Embryos: A Multiple Probe Fluorescence In Situ Hybridization (FISH) Study. Am.J.Hum.Genet. 55,1:150-159.
  • Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J (1993) diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 8:2185-2191
  • Munné S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J, Gianaroli L (1997) Treatment-related chromosome abnormalities in human embryos. Human Reprod, 12:780-784
  • Munné S, Magli C, Bahçe M, Fung J, Legator M, Morrison L, Cohen J, Gianaroli L (1998)Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22. Prenat Diagn. 18:1459-1466
  • Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, Tucker M, Márquez C, Sable D, Ferraretti AP, Massey JB, Scott R (1999) Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Human Reprod, 14:2191-2199
  • Munné S, Márquez C, Magli C, Morton P, Morrison (1998) Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21. Human Molec Reprod 9:863-870
  • Munné S, Márquez C, Reing A, Garrisi J, Alikani M (1998) Chromosome abnormalities in embryos obtained following conventional IVF and ICSI. Fertil Steril 69:904-908
  • Munné S, Morrison L, Fung J, Márquez C, Weier U, Bahçe M, Sable D, Grundfelt L, Schoolcraft, Scott R, Cohen J (1998). Spontaneous abortions are reduced after pre-conception diagnosis of translocations. J Assist Reprod Genet 290-296
  • Munné S, Sandalinas M, Alikani M, Cohen J (2004) Chromosome abnormalities in human embryos. In: Textbook of Assisted Reproductive Technology. Laboratory and Clinical Perspectives. David K Gardner, Weissman A, Howles CM, Shoham Z, Dunitz M Eds. Chapter 28
  • Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J (2000) Outcome of preimplantation genetic diagnosis of translocations. Fertil Steril. 73:1209-1218
  • Munné S, Sandalinas M, Escudero T, Marquez C, Cohen J (2002) Chromosome mosaicism in cleavage stage human embryos: evidence of a maternal age effect. Reprod Biomed Online 4:223-232
  • Munné S, Sandalinas M, Escudero T, Velilla E, Walmsley R, Sadowy S, Cohen J, Sable D (2003) Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reprod Biomed Online, 7:91-97
  • Munné S, Sandalinas M, Magli M, Gianaroli L, Cohen J, Warburton D (2004) Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenat Diagn. 24:638-647
  • Munné S, Scott R, Sable D, Cohen J (1998) First pregnancies after pre-conception diagnosis of translocations of maternal origin. Fertil Steril 69:675-681
  • Munné S, Sepulveda S, Balmaceda J, Fernandez E, Fabres C, Mackenna A, Lopez T, Crosby JA, Zegers-Hochschild F (2000) Selection of the most common chromosome abnormalities in oocytes prior to ICSI. Prerat Diagn 20:582-586
  • Munné S, Serena C, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P2, Fischer J, Garrisi M, Tomkin G, Cohen J (2007) Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reproductive Biomedicine Online 14:628-634
  • Munné S, Sultan KM, Weier HUG, Grifo J, Cohen J, Rosenwaks Z (1995) Assessment of numerical abnormalities of X, Y, 18 and 16-chromosomes in preimplantation human embryos prior transfer. Am. J. Obs. Gyn 172:1191-1201
  • Munné S, Velilla E, Colls P, Garcia-Bermudez M, Vemuri MC, Steuerwald N, Garrisi J, Cohen J (2005) Self correction of chromosomally abnormal embryos in culture and implications for stem cell production. Fertil Steril, 84:331-335
  • Munné S, Weier HUG, Grifo J, Cohen J (1994) Chromosome mosaicism in human embryos. Biol. Reprod. 51:373-379
  • Munné S, Weier, U (1996) Simultaneous enumeration of chromosomes 13, 18, 21, X and Y in interphase cells for preimplantation genetic diagnosis of aneuploidy. Cytogenet. Cell. Genet 75:263-270
  • Munné S, Wells D (2002) Preimplantation genetic diagnosis. Current Opinion Obstet Gynecol 14: 239-244
  • Munné, S. (2005) Preimplantation genetic diagnosis for chromosome abnormalities. In Jorde, L.B., Little, P.F.R., Dunn, M.J. and Subramaniam, S. (Eds), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. John Wiley & Sons Ltd: Chichester, volume , pp. 176.
  • Obasaju M, Kadam A, Biancardi T, Sultan K, Fateh M, Munné S (2001) Pregnancy rate from the transfer of a single normal embryo in women over 40 years of age undergoing PGD for chromosomal abnormalities. Reproductive Biomedicine Online 2:98-101
  • Obasaju M, Kadam A, Sultan K, Fateh M, Munné S (1999) Evidence that sperm quality may adversely affect the chromosome constitution of embryos resulting from ICSI. Fertil. Steril. 1113-1115
  • Otani T, Roche M, Mizuikea M, Colls P, Escudero T, Munné S (2006) Preimplantation genetic diagnosis significantly improves the pregnancy outcome of translocation carriers with a history of recurrent miscarriage and unsuccessful pregnancies. Reproductive Biomed Online 13:869-874
  • Palermo G, Munné S and Cohen J (1994) The human zygote inherits its mitotic potential from the male gamete. Hum.Reprod. 9:1220-1225.
  • Sandalinas M, Márquez M, Munné S (2002) Spectral karyotyping of unfertilized and non-inseminated oocytes. Molec Human Reprod, 8:580-585
  • Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. (2001)Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Human Reprod, 16:1954-1958
  • Santiago Munné, Muhterem Bahçe, Mireia Sandalinas, Tomás Escudero, Carmen Márquez, Esther Velilla, Pere Colls, Maria Oter, Mina Alikani, Jacques Cohen (2004)Differences in chromosome susceptibility to aneuploidy and survival to first trimester. Reproductive Biomedicine Online 8:81-90
  • Silber S, Escudero T, Lenahan K, Sadowy S, Abdelhadi I, Kilani Z, Munné S (2003) Chromosomal abnormalities in embryos derived from TESE. Fertil Steril, 30-38
  • Stachecki J, Cohen J, Munné S (2005) Cryopreservation of biopsied cleavage stage biopsied embryos. Reproductive Biomed online 6:711-715
  • Stachecki J, Munné S, Cohen J (2004) Spindle organization after cryopreservation of mouse, human, and bovine oocytes. Reprod Biomed Online 8:664-672
  • Steuerwald N, Bermudez M, Wells D, Munné S, Cohen J (2007) Maternal age-related differential global expression profiles observed in human oocytes. Reproductive Biomed. Online 14:700-708
  • Templado C, Marquez C, Munné S, Colls P, Martorell MR, Cieply K, Benet J, Van Kirk V, Navarro J, Estop AM (1996) An analysis of human sperm chromosome aneuploidy. Cytogenet Cell Genet 74:194-200
  • Velilla E, Escudero T, Munné S (2002) Blastomere fixation techniques and risk of misdiagnosis for PGD of Aneuploidy. Reprod Biomed Online, 4:210-217
  • Verlinsky, Y, Cohen J, Munné S, Gianaroli L, Simpson JL, Ferraretti AP, Kuliev A (2004)Over a decade of preimplantation genetic diagnosis experience – a multicenter report . Fertil Steril 82:292-294
  • Weier HUG, Munné S, Fung J (1999) patient-specific probes for Preimplantion genetic diagnosis (PGD) of structural and numerical aberrations in interphase cells. J. Assisted Reprod Genet 16:182-191
  • Weier HUG, Munné S, Lersch RA, Hsieh HB, Smida J, Chen XN, Korenberg JR, Pedersen RA, Fung J (2001) Towards a full karyotype screening of interphase cells: ‘FISH and chip’ technology. Molec Cell Endocrinol. 183: S41-S45
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