Reprogenetics

Experts in Preimplantation Genetic Diagnosis

Posted on Wednesday, June 1st, 2016

TRUMBULL, Conn., June 1, 2016 – CooperSurgical a leading provider of women’s health care and Assisted Reproductive Technology (ART) solutions has acquired Reprogenetics UK of Oxford, United Kingdom. Reprogenetics UK is one of the preeminent genetics laboratories specializing in preimplantation screening (PGS) and preimplantation diagnosis (PGD) in Europe. Reprogenetics UK will maintain its close association with Reprogenetics, its US counterpart, while being folded into CooperSurgical’s formidable... Read→

Posted on Wednesday, May 25th, 2016

PLEASANTON, Calif., May 25, 2016 – The Cooper Companies, Inc. (NYSE: COO) today announced that CooperSurgical has acquired the commercial assets of Recombine Inc., a clinical genetic testing company specializing in carrier screening. The transaction is valued at approximately $85 million and is expected to be neutral to earnings per share in fiscal 2016 and accretive thereafter, excluding one-time charges and deal-related amortization. As of April 30, 2016, Recombine had trailing twelve month revenues... Read→

Posted on Monday, June 15th, 2015

NEW YORK (GenomeWeb) – Researchers from the preimplantation genetics laboratory at Reprogenetics have shown that elevated levels of mitochondrial DNA lead to lower success rates for in vitro fertilization procedures. In a study published recently in PLOS Genetics, the firm found that embryos with mtDNA levels above a certain threshold never successfully implant in women undergoing IVF and that quantifying mtDNA in embryos before implantation can boost IVF success rates. Reprogenetics already... Read→

Posted on Monday, June 15th, 2015

Reprogenetics Pioneers New Test, MitoGrade™ to Help Select Embryos More Likely to Result in Viable Pregnancies Through In Vitro Fertilization (IVF) Newly published research demonstrates increased levels of mitochondrial DNA may explain why up to one-third of implantations fail when transferring a chromosomally normal embryo LIVINGSTON, NJ-June 16, 2015 – Reprogenetics, the largest genetics laboratory specializing in Preimplantation Genetic Diagnosis (PGD), announced today new research demonstrating... Read→

Posted on Thursday, February 19th, 2015

Abstract Currently, the methods available for preimplantation genetic diagnosis (PGD) of in vitro fertilized (IVF) embryos do not detect de novo single-nucleotide and short indel mutations, which have been shown to cause a large fraction of genetic diseases. Detection of all these types of mutations requires whole-genome sequencing (WGS). In this study, advanced massively parallel WGS was performed on three 5- to 10-cell biopsies from two blastocyst-stage embryos. Both parents and paternal grandparents... Read→

Posted on Monday, December 1st, 2014

Clinical Sequencing News October 01, 2014 Monica Heger NEW YORK (GenomeWeb) – An ongoing clinical trial of a single-cell sequencing method for preimplantation genetic diagnosis for couples undergoing in vitro fertilization has resulted in its first healthy baby, Clinical Sequencing News has learned. Jie Qiao, director of the Medical Center for Human Reproduction at Peking University Third Hospital; Fuchou Tang, an assistant professor at Peking University’s Biodynamic Optical Imaging Center;... Read→

Posted on Friday, October 17th, 2014

Reprogenetics is the largest genetics laboratory in the US specializing in preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD), with over 42,000 performed procedures and hundreds of publications. Dr. Santiago Munné and Dr. Jacques Cohen founded Reprogenetics in 2000 after extensive experience with PGD and In Vitro Fertilization (IVF). Reprogenetics offers the latest technology in comprehensive chromosome screening, routinely investigates the accuracy of new protocols... Read→

Posted on Friday, August 1st, 2014

Dr. Dagan Wells and Dr. Santiago Munne recently published another article on Next Generation Sequencing (NGS) for use in preimplantation genetics. NGS has the potential to provide the whole genome sequence of an embryo, detect chromosome count, inherited and de novo gene defects, and traits. However, the current cost of a whole sequencing a cohort of embryos is still prohibitive. There are alternatives that are enabling a reduction in the analysis cost and our scientific team is evaluating the amount... Read→

Posted on Thursday, May 15th, 2014

The ASRM General Program Prize – Fragouli et al (mtDNA) The ESHRE Basic Science Prize – Jaroudi et al (telomeres) The ESHRE Clinical Science prize – Wells et al (NGS) The Fertility Society of Australia Exchange Award – Jaroudi et al (telomeres)  Read More →

Posted on Monday, March 10th, 2014

Handyside A. and Wells, D. (2013) High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis. Gamete and embryo assessment in assisted reproduction: emerging technologies. P135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. (Springer Scientific).  Read More →

Posted on Monday, December 16th, 2013

Implantation Rates Improved and Miscarriages Decreased When Women Undergo Genetic Screening During IVF Read article here  Read More →

Posted on Tuesday, November 12th, 2013

For several women having a baby can be extremely emotional and also costly. But one local fertility doctor is hoping that a new study will give more couples the gift of life. See the video here  Read More →

Posted on Thursday, October 10th, 2013

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Posted on Wednesday, October 9th, 2013

Reprogenetics is experiencing a disruption in our phone service. Please use the following numbers to reach us. PGD Laboratory pgdteam@reprogenetics.com 973-462-5331 Client and Patient Services patientservices@reprogenetics.com 973-727-3829 Billing Questions 917-916-7603 reprogeneticsbilling@reprogenetics.com Genetic Counseling pgd-gc@reprogenetics.com 973-818-7184 Management Team Kelly Ketterson 908-612-6332 Jack Loprete 908-692-7355  Read More →

Posted on Tuesday, October 1st, 2013

Dr. Michael Glassner and his patients – the Levys. Connor Levy is the first baby in the world born after IVF and preimplantation genetic diagnosis (PGD) using the Next Generation DNA Sequencing (NGS) technique. NGS increases the chance of transferring an embryo that is most likely to implant, reduces miscarriage rate, and reduces the time and cost to achieve a healthy baby by reducing the number of repeat IVF cycles. See the video here  Read More →

Posted on Thursday, August 22nd, 2013

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Posted on Saturday, August 10th, 2013

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Posted on Wednesday, July 10th, 2013

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Posted on Sunday, July 7th, 2013

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Posted on Monday, March 25th, 2013

Can China really breed a crop of genetically selected geniuses? Read the article here  Read More →

Posted on Tuesday, April 10th, 2012

A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles.  Although euploidy rate decreased on average with advancing maternal age,... Read→

Posted on Monday, April 9th, 2012

Abstract This study retrospectively analysed array comparative genomic hybridization (CGH) results of 7753 embryos from 990 patients to determine the frequency of embryonic euploidy and its relationship with the cohort size (i.e. the number of embryos available for biopsy and array CGH analysis). Linear regression analysis was performed to assess the effect of cohort size on euploidy rate adjusted for the effect of female age. While increasing female age was associated with a significant decrease... Read→

Posted on Sunday, January 29th, 2012

“Focus on Array Comparative Genomic Hybridization Santiago Munné, PhD, head of Reprogenetics, Livingston, NJ, had helped to develop the first PGD test in the early 1990s. In 2001 he created Reprogenetics, the first laboratory in the United States to be accredited to perform PGD. The work performed by Dr Munné and his team these days focuses on array comparative genomic hybridization (aCGH). This technique highlights the presence of defects such as microdeletions and duplications in the DNA... Read→

Posted on Tuesday, October 18th, 2011

Reprogenetics laboratories were the first in the United States and Europe to use Next Generation Sequencing (NGS) for the purpose of identifying embryos with the greatest potential to produce a viable pregnancy. The first baby using this technique was born in 2013 after embryo analysis undertaken by Reprogenetics. A new technique called Karyomapping, which allows embryos to be tested for serious inherited conditions, is now available through Reprogenetics. The technique has been fully validated and... Read→

Posted on Thursday, July 28th, 2011

In a recent article on Bloomberg.com, Dr. Mina Alikani of Reprogenetics and Tyho-Galileo Research Labs comments on the process of embryonic stem-cell line approval. According to the article, in June alone, 37 stem cell lines were approved by the NIH for tax-payer funded research. Three of these approved lines were derived at Reprogenetics. This brings the national total to 128 U.S. endorsed lines. Despite the surge in approvals, Dr. Alikani comments on the still-politicized nature of embryonic stem... Read→

Posted on Wednesday, July 20th, 2011

Preimplantation Genetic Diagnosis (PGD) involves removal of one to 10 cells from human embryos developing in vitro and allows diagnosis of chromosome abnormalities at those early stages.  At the 2011 Annual Meeting of ESHRE, Reprogenetics researcher, Dr. Elpida Fragouli, was honored with the Basic Science Award for her work on alternatives to embryo biopsy and conventional PGD. Dr. Fragouli’s paper described her team’s work on testing cells associated with the egg and the follicle for altered... Read→

Posted on Thursday, July 7th, 2011

German Parliament Allows Some Embryo Screening According to Reuters, German lawmakers have approved a new measure to allow limited screening of human embryos for possible life-threatening genetic diseases.   “The Bundestag moved to allow some pre-implantation genetic diagnosis, or PGD, by a wide, non-partisan margin. But it also imposed strict conditions: Doctors can perform the screening only when the parents have a strong likelihood of passing on a genetic defect, or when the chances of... Read→

Posted on Thursday, June 30th, 2011

In a recent presentation, a PGD laboratory where SNP arrays are used instead of array CGH for diagnosis of aneuploidies in embryos, the accuracy of array CGH was questioned and it was incorrectly stated that the test classifies 8% of embryos as normal when in fact they are polyploid. Reprogenetics has recently published the validation of array CGH (link to Gutierrez Mateo et al. 2011, Fertil Steril, 95:953–8 in pubmed) for aneuploidy diagnosis.  Our results indicate that after reanalysis of embryos... Read→

Posted on Thursday, June 30th, 2011

Reprogenetics researchers have published a study detailing the work that led to live births following preimplantation genetic diagnosis (PGD) in couples that were carriers of translocations. The study is unique because the methods used allowed simultaneous analysis of abnormalities caused by changes in the structure of chromosomes (translocations) and abnormalities in chromosome number (aneuploidy). Moreover, all the chromosomes in each cell were screened rather than a limited number, as it is usually... Read→

Posted on Friday, May 13th, 2011

In an effort to improve our already top-notch customer support, Reprogenetics has launched a new website. The site has more information about our tests, our ordering process, and provides patients with a portal that answers questions they may have concerning our procedures. Also new to the site is an “Ask Us a Question” feature for both patients and providers. This will allow for quick and easy responses from the Client Services team. We hope that clients will take advantage of this... Read→