Reprogenetics

A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles.  Although euploidy rate decreased on average with advancing maternal age,... Read→

Abstract This study retrospectively analysed array comparative genomic hybridization (CGH) results of 7753 embryos from 990 patients to determine the frequency of embryonic euploidy and its relationship with the cohort size (i.e. the number of embryos available for biopsy and array CGH analysis). Linear regression analysis was performed to assess the effect of cohort size on euploidy rate adjusted for the effect of female age. While increasing female age was associated with a significant decrease... Read→

“Focus on Array Comparative Genomic Hybridization Santiago Munné, PhD, head of Reprogenetics, Livingston, NJ, had helped to develop the first PGD test in the early 1990s. In 2001 he created Reprogenetics, the first laboratory in the United States to be accredited to perform PGD. The work performed by Dr Munné and his team these days focuses on array comparative genomic hybridization (aCGH). This technique highlights the presence of defects such as microdeletions and duplications in the DNA... Read→

Congratulations to Dagan Wells, PhD and Reprogenetics for winning the SART Prize Paper at the 67th Annual Meeting of the American Society for Reproductive Medicine (ASRM) in Orlando, FL view here  Read More →

Researchers at Reprogenetics have published a study demonstrating the high accuracy of a new technique, called array CGH (aCGH), for analysis and screening of all chromosomes in human embryos. The authors report that errors or potential misdiagnoses occur very rarely with this technique. In the case of individual blastomeres from day-3 embryos, the error rate is only 1.8%, despite complications arising from mosaic embryos; these are embryos with a mix of normal and abnormal cells. They are known... Read→